Penicillin Cocktail Drink

Penicillin

A shot of Gavin Wrigley looking to the camera in a dimly lit room
Written by Gavin Wrigley
Andrea
Tested by
Andrea Ottaiano

Craving a unique drink? This Penicillin cocktail recipe is easy to make with just a few ingredients!

Penicillin Cocktail Recipe Card

Try our simple Penicillin Cocktail recipe, where Scotch meets a burst of lemon and the sweet warmth of honey-ginger syrup.

Prep time:

1 minute

Mixing time:

2 minutes

Servings:

1

Calories:

212 kl

Ingredients

  • 2 oz Blended Scotch whisky
  • ¾ oz fresh lemon juice
  • ¾ oz honey-ginger syrup
  • ¼ oz Islay single malt Scotch
  • Ice cubes
  • Candied ginger or lemon twist, for garnish, optional

Equipment

  • Rocks Glass
  • Measuring Jigger
  • Cocktail Shaker
  • Strainer

Instructions

  • Prep Glass: Fill your rocks glass with ice cubes to chill.
  • Combine Ingredients: In the cocktail shaker, combine ¾ oz fresh lemon juice, ¾ oz honey-ginger syrup, and 2 oz Blended Scotch whisky.
  • Shake: Fill the shaker with ice and shake it well until the mixture is sufficiently chilled.
  • Strain: Replace the ice in your rock glass with fresh ice cubes and strain the shaken mixture.
  • Float the Scotch: Gently pour ¼ oz Islay single malt Scotch that it floats atop the drink.
  • Garnish: Add candied ginger or a lemon twist to the glass for garnish.
  • Serve: Enjoy your Penicillin Cocktail right away. Cheers!

Notes

Substitutes:

If you don't have Scotch or want a different flavor profile, consider using bourbon or rye whiskey. They alter the taste but create an interesting twist. I've tried a drop of liquid smoke or a smoked sea salt rim on the glass for a smoky undertone without Islay Scotch. As for the honey-ginger syrup, a simple ginger syrup or even a dash of ginger liqueur combined with honey syrup can do the trick if you're in a pinch.

Making a Pitcher of Penicillin Cocktail:

  • Scale: To create a pitcher serving 8 people, multiply all the ingredients by 8. That's 16 oz of blended Scotch, 6 oz of lemon juice, 6 oz of honey-ginger syrup, and 2 oz of Islay Scotch.
  • Mix: In a large pitcher, combine the blended Scotch, lemon juice, and honey-ginger syrup. Stir thoroughly.
  • Serve: Serve the mixture into ice-filled rocks glasses, float the Islay Scotch on top, garnish as desired, and serve immediately.

Making it Non-Alcoholic:

For a non-alcoholic version, I recommend using non-alcoholic whisky alternatives available in the market for the Scotch. They don't replicate the flavor perfectly but can offer a similar complexity. Instead of Islay Scotch, you might use a few drops of smoky tea (like Lapsang Souchong) to introduce that signature smokiness. Follow the rest of the recipe as is, substituting only these components.

Making it Vegan:

Honey is not vegan, so for a vegan Penicillin, I substitute the honey in the honey-ginger syrup with agave nectar or a vegan honey alternative, which are plant-based and have a similar sweetness profile. The rest of the cocktail is typically vegan, but it's always good practice to check the labels of your spirits to ensure they're free of animal products.

Nutrition Facts

Calories
212
% Daily Value*
Fat
 
0.1
g
0
%
Saturated Fat
 
0.01
g
0
%
Sodium
 
1
mg
0
%
Carbohydrates
 
15
g
5
%
Fiber
 
0.1
g
0
%
Sugar
 
14
g
16
%
Potassium
 
31
mg
1
%
Protein
 
0.2
g
0
%
Vitamin A
 
1
IU
0
%
Vitamin C
 
8
mg
10
%
Calcium
 
3
mg
0
%
Iron
 
0.1
mg
1
%

 

Penicillin Cocktail Drink

Penicillin Cocktail Recipe Card

Gavin Wrigley Written by Gavin Wrigley
Jump to Video
Try our simple Penicillin Cocktail recipe, where Scotch meets a burst of lemon and the sweet warmth of honey-ginger syrup.
Prep time: 1 minute
Mixing time: 2 minutes
Servings: 1
Calories: 212

Ingredients
 

  • 2 oz Blended Scotch whisky
  • ¾ oz fresh lemon juice
  • ¾ oz honey-ginger syrup
  • ¼ oz Islay single malt Scotch
  • Ice cubes
  • Candied ginger or lemon twist - for garnish, optional

Equipment

  • Rocks Glass
  • Measuring Jigger
  • Cocktail Shaker
  • Strainer

Instructions

  • Prep Glass: Fill your rocks glass with ice cubes to chill.
  • Combine Ingredients: In the cocktail shaker, combine ¾ oz fresh lemon juice, ¾ oz honey-ginger syrup, and 2 oz Blended Scotch whisky.
  • Shake: Fill the shaker with ice and shake it well until the mixture is sufficiently chilled.
  • Strain: Replace the ice in your rock glass with fresh ice cubes and strain the shaken mixture.
  • Float the Scotch: Gently pour ¼ oz Islay single malt Scotch that it floats atop the drink.
  • Garnish: Add candied ginger or a lemon twist to the glass for garnish.
  • Serve: Enjoy your Penicillin Cocktail right away. Cheers!

Notes

Substitutes:

If you don't have Scotch or want a different flavor profile, consider using bourbon or rye whiskey. They alter the taste but create an interesting twist. I've tried a drop of liquid smoke or a smoked sea salt rim on the glass for a smoky undertone without Islay Scotch. As for the honey-ginger syrup, a simple ginger syrup or even a dash of ginger liqueur combined with honey syrup can do the trick if you're in a pinch.

Making a Pitcher of Penicillin Cocktail:

  • Scale: To create a pitcher serving 8 people, multiply all the ingredients by 8. That's 16 oz of blended Scotch, 6 oz of lemon juice, 6 oz of honey-ginger syrup, and 2 oz of Islay Scotch.
  • Mix: In a large pitcher, combine the blended Scotch, lemon juice, and honey-ginger syrup. Stir thoroughly.
  • Serve: Serve the mixture into ice-filled rocks glasses, float the Islay Scotch on top, garnish as desired, and serve immediately.

Making it Non-Alcoholic:

For a non-alcoholic version, I recommend using non-alcoholic whisky alternatives available in the market for the Scotch. They don't replicate the flavor perfectly but can offer a similar complexity. Instead of Islay Scotch, you might use a few drops of smoky tea (like Lapsang Souchong) to introduce that signature smokiness. Follow the rest of the recipe as is, substituting only these components.

Making it Vegan:

Honey is not vegan, so for a vegan Penicillin, I substitute the honey in the honey-ginger syrup with agave nectar or a vegan honey alternative, which are plant-based and have a similar sweetness profile. The rest of the cocktail is typically vegan, but it's always good practice to check the labels of your spirits to ensure they're free of animal products.

What is a Penicillin Cocktail?

A Penicillin Cocktail blends Scotch whisky, fresh lemon juice, and honey-ginger syrup. The drink owes its name to its soothing and comforting qualities, reminiscent of the healing nature of the antibiotic named after. Listed under ‘New Era Drinks,’ this cocktail has earned recognition from the International Bartender Association (IBA).

A side shot of a Penicillin cocktail in a rocks glass on a wooden tray surrounded by three lemons, a jigger, a shaker, and a bowl with ginger and lemon.

What is in a Penicillin Cocktail – The ingredients

Ready to mix your Penicillin Cocktail? Start by assembling these ingredients:

  • Blended Scotch Whisky: Provides a strong, smooth base that carries the distinct flavors of the cocktail.
  • Lemon Juice: Adds a fresh, zesty tang, balancing the whisky’s richness.
  • Honey-Ginger Syrup: Infuses the drink with a sweet yet spicy kick, complementing the Scotch’s smoky notes.
  • Islay Single Malt Scotch: Floats on top for an aromatic, smoky finish that enhances the cocktail’s complexity.
  • Ice Cubes: Chills and slightly dilutes the mixture for a refreshing, sippable experience.
  • Candied Ginger or Lemon Twist (optional): Serves as a garnish, adding a decorative touch and an extra hint of ginger or citrus.

Blended Scotch Whisky, honey ginger syrup, Islay Scotch, ginger and two lemons laid out on a white bar table.

How do you make a Penicillin Cocktail?

Create a delicious Penicillin Cocktail by following our easy steps:

1
<p>Start by filling your rocks glass with ice cubes to chill it while you prepare the cocktail.</p>

Start by filling your rocks glass with ice cubes to chill it while you prepare the cocktail.

2
<p>Pour the honey-ginger syrup into the cocktail shaker.</p>

Pour the honey-ginger syrup into the cocktail shaker.

3
<p>Add the lemon juice to the cocktail shaker.</p>

Add the lemon juice to the cocktail shaker.

4
<p>Add the blended Scotch to the shaker.</p>

Add the blended Scotch to the shaker.

5
<p>Add ice cubes to the shaker.</p>

Add ice cubes to the shaker.

6
<p>Shake the mixture well until you feel it has chilled sufficiently, which usually takes about 15 seconds.</p>

Shake the mixture well until you feel it has chilled sufficiently, which usually takes about 15 seconds.

7
<p>Remove the ice from your chilled rocks glass, and add fresh ice cubes.</p>

Remove the ice from your chilled rocks glass, and add fresh ice cubes.

8
<p>Strain the shaken mixture into the glass, leaving the ice behind in the shaker.</p>

Strain the shaken mixture into the glass, leaving the ice behind in the shaker.

9
<p>Carefully pour the Islay Scotch so it floats on top of the drink, adding a smoky aroma and flavor.</p>

Carefully pour the Islay Scotch so it floats on top of the drink, adding a smoky aroma and flavor.

10
<p>Garnish the cocktail with candied ginger or a lemon twist to enhance the visual appeal and add a subtle extra flavor.</p>

Garnish the cocktail with candied ginger or a lemon twist to enhance the visual appeal and add a subtle extra flavor.

11
<p>Enjoy your Penicillin cocktail!</p>

Enjoy your Penicillin cocktail!

What is the best blended Scotch for the Penicillin cocktail?

Let’s zero in on the heart of the drink: a quality blended Scotch forms the base, and Compass Box Great King Street Artist’s Blend reigns supreme here. It’s smooth, affordable, and mixes incredibly well, thanks to its soft, fruity character with a subtle hint of smoke. An Islay single malt does the trick for the signature smoky top layer. Laphroaig 10, known for its bold peatiness, infuses the cocktail with unmistakable intensity and a hint of maritime saltiness, complementing the sweetness underneath. Alternatively, for a slightly milder smoky note, try Ardbeg 10. It maintains the characteristic Islay peatiness but brings a complex mix of citrus and sweetness that dances beautifully with the honey and ginger. Remember, the best Scotch for your Penicillin isn’t necessarily the most expensive bottle; it’s the one that balances harmoniously with the other ingredients, creating a cocktail that’s rich in layers and a pleasure to sip.

A Penicillin cocktail, shot from above, in a rocks glass on a wooden tray with a lemon and yellow bowl.

History and Origins of the Penicillin Cocktail

The Penicillin cocktail has a relatively recent history, originating in the early 21st century. Sam Ross, a noted bartender, created this modern classic in 2005 at the famous Milk & Honey bar in New York City. Unlike many historical cocktails, the Penicillin drink didn’t emerge from the annals of time; it was the product of contemporary experimentation and innovation in the world of mixology.

Ross was experimenting with the classic whiskey sour template. He added honey-ginger syrup instead of the traditional simple syrup, aiming for a drink to warm the soul during the cold months. The addition of the Islay Scotch float was a masterstroke, introducing a smoky layer that perfectly complements the spicy-sweet balance of the drink.

The cocktail quickly gained popularity, not just in New York but around the globe, becoming a staple on the menus of craft cocktail bars. Its name, “Penicillin,” hints at its comforting and therapeutic properties, like the famous antibiotic.

A Penicillin cocktail, shot from above, in a rocks glass on a white marmol table surrounded by Blended Scotch Whisky, honey-ginger syrup, Islay Scotch, ginger and two lemons.

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FAQ

How many calories are in a Penicillin cocktail?
A typical Penicillin contains approximately 200-220 calories, depending on the specific quantities of each ingredient used.
How strong is a Penicillin cocktail?
The strength can vary, but generally, it's around 25-30% ABV (Alcohol by Volume), translating to about 50-60 proof, depending on the Scotch's proof and the amount of dilution from shaking/stirring with ice.
What type of alcohol is used in Penicillin?
The primary alcohol is Scotch whisky, specifically a blended for the base, and a peaty Islay Scotch for the float, adding a smoky finish.
What does a Penicillin cocktail taste like?
It offers a harmonious balance of sweet, sour, and smoky flavors, with prominent notes of honey, ginger, and lemon, complemented by the Scotch's complexity.
What's the ratio of ingredients in a Penicillin?
Generally, the Penicillin follows a 2:0.75:0.75 ratio — two parts blended Scotch, ¾ part lemon juice, and ¾ part honey-ginger syrup with a float of peated whisky.
How is the Penicillin cocktail served concerning ice?
It's typically served on the rocks, meaning poured over ice cubes in a rock glass.
In which glass is a Penicillin cocktail served?
Penicillin is traditionally served in a rock glass, also known as an old-fashioned glass.

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