Substitutes:

• Tequila: If you don't have Tequila, you can use mezcal for a smokier flavor or white rum for a lighter, more tropical vibe.
• Fresh Lime Juice: You can use bottled lime juice in a pinch, but the flavor will be less bright and fresh. Another option is to use fresh lemon juice for a slightly different citrus kick.
• Honey Syrup: Agave syrup is an excellent substitute for honey syrup if you prefer a vegan option or want to try something different.
• Ginger Syrup: If you don’t have ginger syrup, you can muddle a small piece of fresh ginger in your shaker with ½ oz simple syrup before making the drink. You can also make your own ginger syrup at home: start by peeling and coarsely chopping some fresh ginger ginger (the more, the spicier the syrup). Then, add it to 17 oz/50 cl boiling water. Cover and let it infuse at room temperature for 3 hours. After this time, give it a taste and infuse it longer if you want a spicier syrup. Once you are satisfied with the infusion, filter through a fine strainer and add 500g of powdered sugar to the ginger water. Mix well to combine, until the sugar is fully dissolved. 
• Mezcal: If you don’t have Mezcal, you can use a peated scotch whisky as an alternative, although the final result won’t come as crisp and fresh.

Making a Pitcher of Medicina Latina:

• Scale: To make a pitcher that serves 8, multiply all the ingredients by 8. That would be 16 oz of Tequila, 8 oz of fresh lime juice, 4 oz of honey syrup, 4 oz of ginger syrup, 4 oz of mezcal, and 8 dashes of lemon bitters.
• Mix: Combine all the ingredients in a large pitcher. Add ice and stir well.
• Serve: Strain to remove the ice, serve immediately into ice-fille rocks glasses, and garnish with candied ginger pieces or fresh ginger slices. If you have some leftovers, be sure to keep it in the fridge (make sure no ice cubes are left inside) in an airtight container.

Making it Non-Alcoholic:

• Tequila Substitute: Use a non-alcoholic tequila substitute; several brands are available that mimic Tequila's flavor quite well. Otherwise, you can use fresh orange juice as a substitute. You can also try making your own substitute by mixing together water, a pinch of smoked salt, a splash of tonic, and a bit of agave syrup (to taste).
• Mezcal: Use a non-alcoholic spirit that has a smoky flavor profile, or make a saline solution with smoked salt (simply dissolve the salt in cold water, following a 20% ration of salt to water) and add 2 or 3 dashes to your drink.
• Proceed As Usual: Use this non-alcoholic substitute instead of the regular Tequila and Mezcal, follow the original steps, and enjoy a non-alcoholic version.

Making it Vegan:

• Honey Syrup Substitute: Replace the honey syrup with agave or simple syrup to make this cocktail vegan-friendly. The taste will be slightly different but still delicious, as the agave syrup pairs particularly well with both tequila and mezcal.